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Chronic Stress Effects: What They Mean for Your Immune, Gut, and Hormonal Health

Fatigue, anxiety, and chronic illness often stem from chronic stress effects, but they don’t have to define your life. In my practice, I’ve seen patients heal by focusing on calming their stress physiology and supporting their body’s innate ability to recover. Healing takes time, but the results are profound—better energy, improved immunity, and a calmer mind. Let’s dive into how addressing chronic stress can restore your health and vitality.

WRITTEN BY

Dr. Andrew Neville
ADRENAL FATIGUE SPECIALIST

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The other day, a patient looked at me with tears in her eyes and said, “Before chronic stress effects took over my life, I was the one everyone counted on. Now I can barely count on my own body to get through the day.” This conversation happens in my office almost daily, and it perfectly captures what happens when your stress response system stays in overdrive for too long.

The Ripple Effect of Long-Term Stress on Your Well-Being

Over the past twenty-some years, I’ve worked with thousands of patients who come to me thinking they’re dealing with multiple unrelated health issues. They’ve usually seen specialist after specialist and collected a stack of diagnoses, but no one’s connected the dots. What these doctors miss is how chronic stress effects fundamentally alter the way every system in your body functions.

When chronic stress effects keep your body in this state for months or even years, everything starts to break down.

So many people come to me with a list of symptoms that read like a medical textbook—digestive issues, frequent colds, anxiety, sleep problems. They’re told they have IBS, an anxiety disorder, low libido, or autoimmune disease. But here’s what was really happening: Their bodies had forgotten how to shift out of stress mode.

Think about what happens when you’re startled. Your heart races, your breathing gets shallow, your muscles tense up. That’s normal and healthy—for a few minutes. But when chronic stress effects keep your body in this state for months or even years, everything starts to break down.

How Chronic Stress Effects Disrupt Your Immune System

When stress hormones flood your system day after day, your immune system simply can’t keep up.

My immune system used to bounce back in days. Now even a minor cold knocks me out for weeks.

Last month, a high school teacher came to see me. He’d had four sinus infections in six months, each requiring antibiotics. His previous doctor kept prescribing stronger antibiotics, missing the real issue—chronic stress effects had weakened his immune system’s ability to fight off even minor infections.

Here’s what I typically see in my practice:

  • Getting sick from exposures that never bothered you before (like that friend’s cat you’ve been around for years or sudden seasonal allergies)
  • Cuts and bruises taking weeks instead of days to heal
  • Cold sores popping up every time you have a highly stressful life event
  • A Covid infection turns into Long Covid because of weakened immunity
Chronic stress effects cause digestive issues like IBS, leaky gut, and food allergies. Food allergies occur because of a combination of suppression of both your immune and digestive systems by your overactive stress response system.

Foods you’ve enjoyed your whole life now make you feel sick

Your Gut Knows Before Your Brain Does

Your digestive system often sends the first warning signals about chronic stress effects, but most people miss these early signs.

I see this show up as:

  • That “pit in your stomach” feeling becoming your constant companion
  • Foods you’ve eaten your whole life suddenly causing problems
  • Dealing with bloating so severe people ask if you’re pregnant

Your body can’t tell the difference between running from a tiger and running late for a meeting.

Let me tell you what’s actually happening. Your body is smart—when it senses a threat, it diverts energy from digestion to deal with the perceived emergency. The problem is that your body can’t tell the difference between running from a tiger and running late for a meeting.

The Role of Chronic Stress Effects on Your Hormones and Energy

One of my patients described it perfectly: “It’s like someone unplugged half my power stations.” When chronic stress effects take hold, your body makes a choice—survival over everything else. You can’t run from a tiger and digest dinner at the same time.

What this looks like:

  • Your menstrual cycle becomes unpredictable, even if it’s been regular for years
  • That afternoon energy crash becomes a full-day energy drought
  • Weight starts climbing even though you haven’t changed your diet
One of the most common symptoms of Adrenal Fatigue is the "wired but tired" energy.
One of the most common symptoms of Adrenal Fatigue is the “wired but tired” energy.

When Your Nervous System Gets Stuck

Remember learning to drive? How every little adjustment felt huge—too much gas, too much brake? That’s what happens to your nervous system under prolonged stress. It forgets how to make small adjustments.

When your stress response stays in overdrive, it doesn’t just affect your adrenals – it changes everything

Can you tolerate bright lights and strong smells less and less every day? Did you use to handle your kid’s tantrums and work or social deadlines like a pro? Do you dread someone’s touch because your skin aches, like you have the flu?

Your nervous system has lost its ability to distinguish between minor annoyances and real threats. This is called central sensitization, where your five senses are on high alert all the time. At its worst, this can lead to the diagnosis of Fibromyalgia.

Some other common patterns I see in patients:

  • Feeling simultaneously exhausted and unable to relax
  • Walking into rooms and forgetting why you’re there
  • Lying awake at 3 AM while being barely functional at 3 PM

Finding Your Way Back

Understanding how chronic stress effects have reshaped your body is the first step toward healing. I’ve watched thousands of patients reverse these patterns, but it requires addressing the real problem—a stress response system that’s stuck in high gear.

That’s not just about better sleep—it’s about a body that finally feels safe enough to relax.

I have another patient, Julie, who stopped me as I was reviewing her progress. She had tears in her eyes, but this time, they were different from those at the first appointment. “You know what I did yesterday?” she said. I fell asleep on my couch reading a book, just dozed right off. I haven’t done that since before my kids were born.”

That’s not just about better sleep—it’s about a body that finally feels safe enough to relax. When patients first come to see me, many haven’t experienced that feeling in years. They’ve forgotten it’s even possible.

I’ll be honest with you—this isn’t a quick journey. One of my long-term patients likes to say she didn’t notice she was getting better until her husband pointed out she’d stopped clenching her jaw while watching TV. Another realized she was healing when she made it through an entire winter without getting sick. These small victories add up, telling us your body is remembering its own wisdom.

Read more on the signs of healing here.

WRITTEN BY

Dr. Andrew Neville
ADRENAL FATIGUE SPECIALIST

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